| 货号 | ASC-002-AR-50ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to Nav1.2 Channel Conjugated to the Fluorescent Dye ATTO-594 |
| 反应种属 | H, M, R |
| 应用 | IH |
| 供应商 | Alomone |
| 背景 | Voltage-gated sodium channels (Nav) are essential for the generation of action potentials and for cell excitability1. NaV channels are activated in response to depolarization and selectively allow flow of Na+ ions. To date, nine NaV α subunits have been cloned and named Nav1.1-Nav1.94,5. The Nav channels are classified into two groups according to their sensitivity to Tetrodotoxin (TTX): TTX-sensitive (Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.6 and Nav1.7) and TTX-resistant (Nav1.5, Nav1.8 and Nav1.9)2,3. Mammalian Na+ channels are heterotrimers, composed of a central, pore-forming α subunit and two auxiliary β subunits. The expression of the α subunit is developmentally regulated and tissue specific. Na+ channels in the adult central nervous system and heart contain β1 through β4 subunits, whereas sodium channels in adult skeletal muscle have only the β1subunit6,7. Nav1.2 is primarily expressed in the central nervous system (CNS) and is localized in unmyelinated or premyelinated axons and dendrites. Mutations in the Nav1.2 channel have been identified in different types of epilepsy. |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Wu, L.et al.(2002)NeuroReport13,2547. 2.Fang, X.et al. (2002)J. Neurosci.22,7425. 3.Fjell, J.et al. (2000)NeuroReport11,199. 4.Baker, M.D. and Wood, J.N. (2001) Trends Pharmacol. Sci.22,27. 5.Lai, J. et al.(2003)Curr. Opin. Neurobiol.13,291. 6.Isom, L.L. (2001)Neuroscientist7,42. 7.Catterall, W.A.et al.(2003)Pharmacol. Rev. 55,575. 8.Catterall, W.A.et al.(2008) J. Neurosci.28,11768. |
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