| 货号 | APR-012-AR-50ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to P2Y12 Receptor Conjugated to the Fluorescent Dye ATTO-594 |
| 反应种属 | H, M, R |
| 应用 | IH |
| 供应商 | Alomone |
| 背景 | The P2Y receptors belong to the G-protein coupled receptors superfamily. They mediate the actions of the extracellular nucleotides (ATP, ADP, UTP AND UDPA. Eight functional mammalian P2Y receptors have been described: P2Y1,P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13, and the UDP-glucose receptor, now renamed P2Y14.1-3 The P2Y12 receptor is co-expressed with P2Y1 receptor on platelets leading to shape change, aggregation, and rise in intracellular Ca2+ upon activation. The only other expression of P2Y12 was found in brain, according to results of reverse transcription-polymerase chain reaction and northern blotting.4 The P2Y12 receptor has become a target for potential therapeutic drugs for the treatment of thromboembolism and other clotting disorders.4 |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1. Queiroz, G. et al.(2003)J. Pharmacol. Exp. Ther. 307,809. 2. Ralevic, V. and Burnstock, G. (1998) Pharmacol. Rev. 50,413. 3. Abbracchio, M.P. et al.(2003)Trends. Pharmacol. Sci. 24,52. 4. Nicholas, R.A. (2001) Mol. Pharmacol. 60,416. |
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