| 货号 | AGT-005-AR-50ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to Vesicular GABA Transporter Conjugated to the Fluorescent Dye ATTO-594 |
| 反应种属 | H, M, R |
| 应用 | IH |
| 供应商 | Alomone |
| 背景 | The superfamily of amino acid transporters includes SLC32, SLC36 and SLC38 families. SLC32 has only one family member, the vesicular inhibitory amino acid transporter (VIAAT) or vesicular GABA transporter (VGAT)1. VGAT is responsible for the uptake of GABA and Glycine in exchange of protons, and their release from nerve terminals1. The transporter is organized into ten membrane spanning domains, a cytosolic N-terminus and a luminal C-terminal tail2. In many regions in the brain, where it is expressed, it is found constitutively phosphorylated, although the biological significance is currently unknown3. VGAT is expressed on synaptic vesicles of GABAergic and glycynergic neurons4-6. The transporter is also detected in the pituitary gland and in the pancreas7,8. |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Gasnier, B.(2004)Pflugers Arch.447,756. 2.McIntire, S.et al.(1997)Nature389,870. 3.Bedet, C.et al.(2000)J. Neurochem.75,1654. 4.Chaudhry, F.A.et al.(1998)J. Neurosci.18,9733. 5.Dumoulin, A.et al.(1999)J. Cell Sci.112,811. 6.Takamori, S.et al.(2000)J. Neurosci.20,4904. 7.Mayerhofer, A.et al.(2001)FASEB J.15,1089. 8.Chessler, S.et al.(2002)Diabetes51,1763. |
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