| 货号 | ACC-060-F-50ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to Human Orai1 Channel Conjugated to the Fluorescent Dye FITC |
| 反应种属 | H |
| 应用 | FC |
| 供应商 | Alomone |
| 背景 | Cytosolic calcium (Ca2+) has long been known to act as a key second messenger in many intracellular pathways including synaptic transmission, muscle contraction, hormonal secretion, cell growth, and proliferation.1,2 The mechanism controlling intracellular Ca2+ level influx either by calcium-release-activated Ca2+ channels (CRAC) or from intracellular stores has become of great interest. Recently, several key players of the store-operated complex have been identified.3 Orai1 (also known as CRACM1) acts as the store-operated calcium channel (SOC) and STIM1 acts as an endoplasmic reticulum (ER) Ca2+ sensor.3,4 The formation of functional channels requires the presence of both Orai1 and STIM1 proteins working as a complex that involves co-clustering of Orai1 on the plasma membrane with STIM1 on the ER.4-6 TRPC1, a member of the transient receptor potential family was also suggested to act as a player in the SOC complex.7 In T cells, Ca2+ entry following activation by antigen-receptor engagement occurs solely through CRAC channels where Orai1 constitutes the pore-forming subunit.3,8 Orai1 is a plasma membrane protein with four potential transmembrane domains and intracellular N- and C-termini. In addition, two mammalian homologs of Orai1 have been identified: Orai2 and Orai3.3,9 All three (Orai1, Orai2, and Orai3) have been shown to be capable of forming store-operated channels.9,10 |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Eisner, D.A. et al. (2005) Exp.Physiol. 90, 3. 2.Chakrabarti, R. and Chakrabarti, R. (2006) J.Cell. Biochem. 99, 1503. 3.Feske, S. et al. (2006) Nature 441, 179. 4.Pickett, J. (2006) Nature Reviews Mol. Cell Biol. 7, 794. 5.Luik, R.M. et al. (2006) J.Cell. Biol.174, 815. 6.Wu, M.M. et al. (2006) J.Cell. Biol.174, 803. 7.Hong H.L. et al. (2007) J. Biol. Chem. 282, 9105. 8.Luik, R.M and Lewis, R.S. (2007) Trends Mol. Med. 13, 103. 9.DeHaven, W.I. et al. (2007) J. Biol. Chem. 282, 17548. 10.Lis, A.et al.(2007)Curr. Biol.17, 794. |
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