| 货号 | ACC-034-AO-50ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to TRPV4 Channel Conjugated to the Fluorescent Dye ATTO-550 |
| 反应种属 | H, M, R |
| 应用 | IH |
| 供应商 | Alomone |
| 背景 | TRP channels are a large family (about 28 genes) of plasma membrane, non-selective cationic channels that are either specifically or ubiquitously expressed in excitable and non-excitable cells1. According to IUPHAR the TRP family comprises of three main subfamilies on the basis of sequence homology; TRPC, TRPM and TRPV (to date, three extra subfamilies are considered to belong to the TRP family; the TRPA, TRPML, and TRPP)1-4. The TRPV subfamily consists of six members, TRPV1-65. TRPV4 (also named OTRPC4) is activated under hypotonic conditions and serves as an osmoreceptor. TRPV4 is expressed in brain, liver, kidney, heart, testis and salivary gland6. Alomone Labs offers a highly specific antibody directed against an intracellular epitope of TRPV4. Anti-TRPV4antibody (#ACC-034) can be used in Western blot, immunocytochemical, and immunohistochemical applications and recognizes TRPV4 from rat samples. |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Montell, C. et al. (2002) Mol. Cell. 9, 229. 2.Clapham, D.E. (2003) Nature 426, 517. 3.Moran, M.M. et al. (2004) Curr. Opin. Neurobiol. 14, 362. 4.Clapham, D.E. et al. (2003) Pharmacol. Rev. 55, 591. 5.Gunthorpe, M.J. et al. (2002) Trends. Pharmacol. Sci. 23, 183. 6.Peng, J.B. et al. (2003) J. Physiol. 551, 729. |
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