| 货号 | AZC-001-50ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to Zinc-Activated Channel (ZAC) |
| 反应种属 | H |
| 应用 | IC, IFC, LCI, WB |
| 供应商 | Alomone |
| 背景 | Over forty homologous proteins belong to the superfamily of ligand-gated ion channels. These members are broken down into different subfamilies, for example: acetylcholine, serotonin and glycine receptors. A new member has been added to this superfamily – ZAC (zinc-activated channel) which is expressed in human and dog but not in rodents1. Like all other ligand-gated ion channels, ZAC has four transmembrane domains and extracellular N- and C-termini. As its name states, the channel is activated by high concentrations of zinc. ZAC mRNA was found to be expressed in placenta, spinal cord, stomach, and fetal brain1. In another study, ZAC was identified using a computer-assisted program and was detected in similar areas (including pancreas and kidney), but also displayed minor discrepancies2. Being that the channel is expressed in human and dog, deciphering its cellular/physiological functions will be challenging. |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Davies, P.A. et al. (2003) J. Biol. Chem. 278, 712. 2.Houtani, T. et al. (2005) Biochem. Biophys. Res. Comm. 335, 277. |
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