| 货号 | ASR-023-50ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to 5-Hydroxytryptamine Receptor 1D |
| 反应种属 | H, R |
| 应用 | WB |
| 供应商 | Alomone |
| 背景 | Serotonin (5-hydroxytryptamine, 5-HT) plays unequivocally a most important role in the normal physiology amongst higher eukaryotes, as do most neurotransmitters. The physiological roles of serotonin and its receptors range from appetite, regulation of the circadian rhythm, sexual behavior, memory and nociception. Serotonin is also involved in migraine and some psychiatric diseases such as depression anxiety and aggression1. Serotonin and its receptors also have an influence on the cardiovascular, pulmonary, gastrointestinal (GI) and genitourinary systems2. To date, some fifteen serotonin receptors have been cloned and grouped into seven families (5-HT1-5-HT7) based on their signaling mechanisms. The 5-HT1 receptor class comprises 5 different receptors with ranging homology. Apart from 5-HT3, all serotonin receptors belong to the G-Protein Coupled Receptor superfamily and therefore span the membrane seven times3. Members of 5-HT1 receptor class all couple Gi/0 thereby inhibiting adenylate cyclase. In the central nervous system, 5-HT1D is expressed in the basal ganglia, hippocampus and cortex in rat and in the basal ganglia, midbrain and spinal cord in human. In serotonin neurons, 5-HT1D receptors are autoreceptors thereby inhibiting the release of 5-HT. In GABA, ACh, and glutamate neurons they are heteroreceptors where they control the release of these neurotransmitters4,5. As mentioned above, the serotonin system plays an undeniable role in the perception and processing of pain. Indeed, many migraine sufferers are prescribed triptan-based drugs which activate 5-HT1B and 5-HT1Dreceptors2. |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen |
| 参考文献 | 1. Sari, Y. (2004) Neurosi. Biobehav. Rev.28,565. 2. Berger, M. et al.(2009)Annu. Rev. Med.60,355. 3.http://www.iuphar-db.org/DATABASE/ReceptorFamiliesForward?type=GPCR. 4. Filip, M. and Bader, M. (2009) Pharmacol. Rep.61,761. 5. Fink, K.B. and Göthert, M. (2007) Pharmacol. Rev.59,360. |
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