| 货号 | ASR-001-50ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to Somatostatin Receptor Type 1 |
| 反应种属 | R |
| 应用 | WB |
| 供应商 | Alomone |
| 背景 | Somatostatin is a small cyclic peptide that is widely expressed throughout the central nervous system and peripheral tissues.1 In peripheral tissues, somatostatin exerts inhibitory effects on secretion processes, whereas in the brain it acts as a neurotransmitter in both stimulatory and inhibitory manner.1, 2 Somatostatin mediates its action via six high affinity G-protein coupled receptors (SSTR1, SSTR2a, SSTR2b, SSTR3, SSTR4 and SSTR5) which are encoded by five genes.1,2 Expression of the different receptors is developmentally regulated in a time and tissue-specific manner.2 Somatostatin receptors have been found on a variety of neuroendocrine tumors, such as paragangliomas, carcinoids and breast tumors.3 Synthetic peptide derivatives of somatostatin have been successfully used in the treatment of neuroendocrine malignancies and in in vivo imaging of tumors that are positive to somatostatin receptors.4 |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1. Hofland, LJ. and Lamberts, S.W.J. (2001) Annals of Oncology12, S31. 2. Fombonne, J. et al.(2003) Rep. Biol. Endocrinol.1, 19. 3. Slooter, G.D. et al. (2001) Br. J. Surg.88, 31. 4. Schulz, S. et al. (2002) Gynecologic Oncology84, 235. |
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