| 货号 | ASC-017-50ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to Nav1.9 Channel |
| 反应种属 | H, R |
| 应用 | IC, IH, WB |
| 供应商 | Alomone |
| 背景 | Voltage-gated Na+ channels (NaV) are essential for the generation of action potentials and for cell excitability.1NaV channels are activated in response to depolarization and selectively allow flow of Na+ ions. To date, nine NaV α subunits have been cloned and named NaV1.1-1.9.2-3 Expression of the α subunit is developmentally and tissue specific. The NaV channels are classified into two groups according to their sensitivity to tetrodotoxin (TTX): TTX-sensitive and TTX-resistant channels.4-5 TTX-resistant channels have been suggested to play an important role in nociceptive transmission. Two TTX-resistant NaV channels are expressed in dorsal root ganglion (DRG) neurons, NaV1.8 and NaV1.9. The NaV1.9 channel (also called NAN or SNS2) is preferentially expressed in small-diameter DRG neurons.4-5 Recently, it was shown that BDNF activates Nav1.9 channels in the hippocampus suggesting that its expression is not restricted to DRG alone. 6 |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Wu, L.et al.(2002)NeuroReport13,2547. 2.Baker, M.D. et al. (2001)Trends. Pharmacol. Sci.22,27. 3.Lai, J. et al(2003)Curr.Opin. Neurobiol13,291. 4.Fang, X.et al (2002)J. Neurosci.22,7425. 5.Fjell, J.et al (2000)NeuroReport11,199. 6.Blum, R.et al (2002)Nature419,687. |
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