| 货号 | APR-064-50ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to Prostanoid EP2 Receptor |
| 反应种属 | H, M, R |
| 应用 | IFC, IH, WB |
| 供应商 | Alomone |
| 背景 | Prostaglandin E2 (PGE2) is involved in a number of physiological and pathophysiological events in many tissues throughout the body1. The physiological actions of PGE2 are mediated through its interaction with cell surface prostaglandin E receptors. There are three pharmacologically defined subtypes of the EP receptor, EP1, EP2, and EP3, and these subtypes are suggested to be different in their signal transduction2. These receptors belong to the G-protein coupled receptor (GPCR) superfamily. Like all members they have seven transmembrane domains with extracellular N-terminal tail and intracellular C-terminus. The EP2 receptor is expressed in the vasculature, the gastrointestinal tract, kidney and also in the ciliary muscles in the eye3. PGE2 is known to play a central role in the pathophysiology of inflammation in synergy with other proinflammatory mediators. PGE2 inhibits the function and the proliferation of T cells and the histamine release from mast cells by increasing the intracellular level of cAMP4. EP2 subtype is thought to be in part responsible for vasodilation, oedema formation, hyperanalgesia, modulation of the immune system, and the breakdown of bone and cartilage associated with disorders such as rheumatoid arthritis5. |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1. Campbell, W.B. et al. (1990) The Pharmacological Basis of Therapeutic8,600. 2. Davies, P. et al. (1992) Inflammation: Basic Principles and Clinical Correlates2,123. 3. Coleman, R.A. et al. (1992) Comprehensive Medicinal Chemistry3,123. 4.Ferreri, N.R. et al. (1992)J. Biol. Chem. 267,9443. 5.Bastien, L. et al. (1994) J. Biol. Chem. 269,11673. |
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