| 货号 | APR-018-50ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to P2Y14 Receptor |
| 反应种属 | H, M, R |
| 应用 | IFC, IH, WB |
| 供应商 | Alomone |
| 背景 | P2Y14 belongs to the P2Y receptor family that is part of the G-protein coupled receptor superfamily. To date eight functional mammalian P2Y receptors have been identified: P2Y1,P2Y2,P2Y4,P2Y6,P2Y11,P2Y12,P2Y13 and P2Y14. The P2Y receptor family mediates the effects of extracellular nucleotides such as ATP, ADP, UTP and in the case of P2Y14 UDP-glucose. UDP-glucose as the other nucleotides can be released to the extracellular milieu as the result of cell damage or by regulated non-lytic mechanisms. P2Y14 is expressed in several tissues including brain, lung and several cells of hematopoietic origin such as T lymphocytes and dendritic cells. The exact function of this receptor in the different tissues has not been clearly established but an involvement in chemotaxis, maturation of immature dendritic cells and neuroimmune regulation has been suggested. |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Chambers, J.K.et al. (2000) J. Biol. Chem.275,10767. 2.Abbracchio, M.P.et al. (2003) Trends Pharmacol. Sci.24,52. 3.Skelton, L.et al. (2003) J. Immunol.171,1941. |
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