| 货号 | APC-061-50ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to sloβ4 Subunit |
| 反应种属 | H, M, R |
| 应用 | IC, IH, WB |
| 供应商 | Alomone |
| 背景 | sloβ4 is a member of a family of regulatory β subunits that control the activity of the large conductanceCa2+-activated K+ channelKCa1.1. The family includes four members with a shared topology: two trans-membrane domains, short intracellular N- and C-termini and a large extracellular region. The four members of the family have a distinct tissue distribution with sloβ4 expressed almost exclusively in the central nervous sytem (CNS). Functionally, sloβ4 increases the sensitivity of the pore-forming KCa1.1 subunit to Ca2+ and voltage and it also changes its pharmacology. It has been shown that co-expression of sloβ4 with KCa1.1 makes the latter resistant to nM concentrations of the well-known inhibitors Charybdotoxin (#STC-325) and Iberiotoxin (#STI-400). The physiological significance of sloβ4 expression in the CNS is not clear, but KCa1.1 channels are likely involved in the regulation of neurotransmitter release in presynaptic terminals. |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Meera, P.et al. (2000) Proc. Natl. Acad. Sci. U.S.A. 97,5562. 2.Orio, P. et al. (2002) News Physiol. Sci.17,156. 3.Brenner, R.et al. (2000) J. Biol. Chem. 275,6453. |
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