| 货号 | APC-044-50ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody K2P9.1 Channel |
| 反应种属 | H, R |
| 应用 | IH, WB |
| 供应商 | Alomone |
| 背景 | K2P9.1 (also named TASK3 or KCNK9) is a member of the 2-pore (2P) domain K+ channels family that probably assemble as dimers to constitute a functional channel.1 These channels show little time or voltage dependence and are considered to be “leak” or “background” K+ channels, thereby generating background currents which help set the membrane resting potential and cell excitation. The channels are regulated by diverse physical and chemical stimuli including temperature, pH, mechanical stretch, inhalation anesthetics, etc.2 The physiological role of the K2P channels is not yet clear, though they were proposed to participate in breathing, aldosterone secretion and anesthetic-mediated neuronal activity. In human, expression of K2P9.1 is restricted in brain and its expression overlaps with the structurally related K2P3.1 (TASK1, KCNK3) channel. In rat, it is more widely expressed in other tissues as well as in brain. Unexpectedly, K2P9.1 was found to be over-expressed between 5 to 100-fold in 44% of breast cancer tumors tested. Transfection and over-expression of K2P9.1 in cell lines promotes tumor growth and confers resistance to hypoxia and serum deprivation.3 Recently, K2P9.1 was found to play an important role in K+-dependent apoptosis of cerebellar granules.4 |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Lesage, F. and Lazdunski, M. (2000) Am. J. Physiol. Renal Physiol. 279, F793. 2.Patel, A.J.et al.(2001)Trends Neurosci. 24,339. 3.Mu, D.et al.(2003)Cancer Cell 3,297. 4.Lauritzen, I.et al.(2003)J. Biol. Chem. 278,232068. |
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