| 货号 | APC-002-50ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to KV1.3 Channel |
| 反应种属 | H, M, R |
| 应用 | IC, IH, IP, WB |
| 供应商 | Alomone |
| 背景 | KV1.3 belongs to the Shaker family of voltage-dependent K+ channels. The channel is widely expressed in the brain, lung and osteoclasts and in several cell populations of hematopoietic origin. It is in these cells (particularly T lymphocytes) that KV1.3 function has centered a lot of attention. It was found that KV1.3 is the main channel. Responsible for maintaining the resting potential in quiescent cells and regulating the Ca2+ signaling that is indispensable for normal T lymphocyte activation.1,2 Based on the central role of Kv1.3 in regulating the initiation of an immune response, the channel has been recognized as a potential target for immunosuppressant drugs.1 KV1.3 channels are potently inhibited by several venomous peptide toxins among them Charybdotoxin (#STC-325, 2.6 nM), Noxiustoxin (#STN-340, 1 nM), Kaliotoxin (#STK-370, 0.65 nM), Margatoxin (#STM-325, 0.05 nM), Agitoxin-1 (#RTA-150, 1.7 nM), Agitoxin-2 (#STA-420, 0.004 nM), Hongotoxin-1 (#RTH-400, 0.09 nM) and Stichodactyla toxin (#RTS-400, 0.01 nM).3-7 |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | The serum was depleted of anti-GST antibodies by affinity chromatography on immobilized GST and from antibodies cross-reactive to other Kv1 by affinity chromatography on immobilized Kv1.1-GST-fusion protein. The antibody was then affinity purified on immobilized Kv1.3-GST. |
| 参考文献 | 1.Chandy, K.G. et al.(2001)Toxicon39,1269. 2.Koo, G.C.et al.(1997)J. Immunol. 158,5120. 3.Grissmer, S.et al.(1994)Mol. Pharmacol. 45,1227. 4.Garcia-Calvo, M.et al.(1993)J. Biol. Chem. 268,18866. 5.Garcia, M.L. et al.(1994)Biochemistry33,6834. 6.Koschak, A.et al. (1998)J. Biol. Chem. 273,2639. 7.Kalman, K.et al. (1998)J. Biol. Chem. 273,32697. |
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