| 货号 | ANT-003-50ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to NT3 |
| 反应种属 | H, M, R |
| 应用 | IH, WB |
| 供应商 | Alomone |
| 背景 | The neurotrophins ("neuro" means nerve and "trophe" means nutrient) are a family of soluble, basic growth factors which regulate neuronal development, maintenance, survival and death in the CNS and the PNS.1 The structural hallmark of all the neurotrophins is the characteristic arrangement of the disulfide bridges known as the cysteine knot, which has been found in other growth factors such as PDGF.2 The rat and human forms of Neurotrophin-3 (NT-3) are 96% homologous. NT-3 has been shown to strengthen synaptic connections to motoneurons in the neonatal rat,3 to serve as an anti-inflammatory factor, to suppress microglial activation,4 to play a critical role in regulating T helper 1/T helper 2 cell balance5 and to modify potassium currents in isolated inner hair cells from guinea pig cochlea.6 The biological effects of NT-3 are mediated by two receptors: TrkC, which is specific for NT-3, and p75NTR, which binds all the neurotrophins.7 |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Roux, P.P. and Barker, P.A.(2002)Prog. Neurobiol. 67,203. 2.McDonald N.Q.et al.(1991)Nature354,411. 3.Arvanian, V.L.et al.(2003)J. Neurosci. 23,8706. 4.Tzeng, S.F. and Huang, H.Y. (2003) J. Cell Biochem. 90,227. 5.Sekimoto, M.et al.(2003)Immunol. Lett. 88,221. 6.Kimitsuki, T.et al.(2003)Auris. Nasus Larynx. 30,141. 7.Teng, K.K. and Hempstead, B.L. (2004) Cell Mol. Life Sci. 61,35. |
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