| 货号 | AMT-004-50ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to Serotonin Transporter (SERT) |
| 反应种属 | H, M, R |
| 应用 | IC, IFC, IH, LCI, WB |
| 供应商 | Alomone |
| 背景 | Many physiological, endocrine and behavioral functions are determined and regulated by monoamine signaling1,2. Many brain disorders such as depression, drug abuse, schizophrenia, attention deficit hyperactivity disorder (ADHD) are caused by the malfunction of monoaminergic transmission1-3. The intensity of monoaminergic signaling is determined by the availability of the monoamine, which is in turn determined in part by its uptake from the extracellular milieu via monoamine transporters. These transporters include DAT, SERT, and NET, responsible for uptaking dopamine, serotonin (5-HT) and noradrenaline respectively, and recycling them back for release3-5. DAT, SERT and NET are members of the Na+/Cl- dependent membrane transporter family which also includes other members. These transporters consist of 12 transmembrane domains and intracellular N- and C-termini. Like its counterparts, SERT’s intracellular N- and C-terminal domains are also subject to phosphorylation and protein-protein interactions important for modulating its activity and localization6. SERTs are evidently expressed in serotonergic neurons, and are also expressed in various peripheral tissues including specialized cells of the gut, placenta, lung, blood lymphocytes and platelets6. SERT knockout mice are viable and as a consequence exhibit increased extracellular levels of 5-HT and significantly decreased levels of brain tissue 5-HT due to deficient recycling and re-accumulation of serotonin by SERT7,8. Phenotypes displayed by SERT knockout mice include stress sensitivity, obesity and various behavioral changes9 |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Haenisch, B. and Bönisch, H.(2011)Pharmacol. Ther.129,352. 2.Ramamoorthy, S. et al. (2010) Pharmacol. Ther. 129, 220. 3.Kim, D.K.et al.(2005)Neuropharmacology49,798. 4.Mathews, T.A.et al.(2004)J. Neurosci. Meth.140,169. 5.Gainetdinov, R.R. and Caron, M.G.(2003)Annu. Rev. Pharmacol. Toxicol.43,261. 6.Greengard, P. (2001) Science. 294, 1024. 7.Miller, G.W. et al. (1999) Trends. Pharmacol. Sci. 20, 424. 8.Amara, S.G. and Kuhar, M.J.(1993) Annu. Rev. Neurosci. 16, 73. 9.Carlsson, A. (1987) Annu. Rev. Neurosci. 10, 19. |
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