| 货号 | AMR-002-50ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to M2 Muscarinic Receptor |
| 反应种属 | H, M, R |
| 应用 | IC, IH, IP, WB |
| 供应商 | Alomone |
| 背景 | The action of the neurotransmitter acetylcholine is mediated through two types of receptors, the ionotropic nicotinic receptors and the metabotropic muscarinic receptors. The muscarinic receptors belong to the superfamily of 7-TM G-protein-coupled receptors. Five subtypes of muscarinic receptors have been cloned and are named m1-m5.1-2 The muscarinic receptors are widely distributed throughout the body but are predominantly expressed within the parasympathetic nervous system and exert both excitatory and inhibitory control over central and peripheral tissues.1-2 Muscarinic receptors participate in a number of physiological functions such as regulation of heart rate, muscle contraction, cognition, sensory processing, and motor control.1 They also participate in learning and memory processing.3-4 The m2 receptor is considered to be the predominant muscarinic receptor that is expressed in cardiac muscle.5 The m2 and m4 receptors mediate Ca2+ channel inhibition and Kir3 K+ channel activation by directly binding the Gβγ subunit to the channel.6,7 Stimulation of the m2 receptor by acetylcholine in the heart results in activation of the Kir3.1/Kir3.4 channels causing a slowing in heart beat.7 |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | The serum was depleted of anti-GST antibodies by affinity chromatography on immobilized GST, and then anti-m2 was affinity purified on immobilized m2-GST. |
| 参考文献 | 1.Felder, C.C.et al. (2000) J. Med. Chem.43,4333. 2.Forsythe, S.M.et al.(2002)Am. J. Respir. Cell. Mol. Biol.26,298. 3.Ferreira, A.R.et al.(2003)Pharmacol. Biochem. Behav.74,411. 4.Van der Zee, E.A. and Luiten, P.G. (1999) Prog. Neurol.58,409. 5.Tata, A.M.et al. (1999) Brain Res.824,63. 6.Shapiro, M.S.et al.(1999)Proc. Natl. Acad. Sci. U.S.A. 96,10899. 7.Jin, W. and Lu, Z.(1998)Biochemistry 37,13291. |
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