| 货号 | ALR-001-50ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to Human BLT1 |
| 反应种属 | H |
| 应用 | IFC, WB |
| 供应商 | Alomone |
| 背景 | Leukotrienes (LTs) are lipid mediators prominently exerting proinflammatory responses. They are divided in two classes: cysteinyl LTs (cysLTs) which have a thioester linkage and LTB41. LTB4, a chemoattractant plays a prominent role in the recruitment and activation of leukocytes2. LTB4 acts through two receptors which belong to the G-protein coupled receptor superfamily: BLT1 and BLT2. BLT1 displays high affinity for LTB4 and is highly expressed in leukocytes including granulocytes, macrophages, mast cells, dendritic cells and effector T cells3 and is expressed to much lower levels in spleen, thymus, heart, skeletal muscle brain and liver2-4. BLT2 on the other hand is a low affinity receptor which does not display selectivity towards LTB45. Its expression is much more ubiquitous than that of BLT1. It is expressed in most human tissues, with the highest expression being in spleen, liver, ovary, and leukocytes2,5-8. The two receptors could couple and activate different G-proteins, depending on the cell type and the cellular events activating the receptors2. However, activation of BLT1 ususally correlates with increasing intracellular concentrations of Ca2+. The LTB4/BLT1 system is involved in many allergic reactions as well as asthma induced as an allergic response, where it plays a significant role in recruiting neutrophils and effector T cells into lungs, as part of an inflammatory response induced by allergens1. |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1. Riccioni, G. et al.(2008)J. Leukoc. Biol.84,1374. 2. Tager, A.M. and Luster A.D. (2003) Prostaglandins Leukot. Essent. Fatty Acids69,123. 3. Yokomizo, T. et al.(1997)Nature387,620. 4. Owman, C. et al.(1996)Genomics37,187. 5. Yokomizo, T. et al.(2000)J. Exp. Med.192,421. 6. Tryselius, Y. et al.(2000)Biochem. Biophys. Res. Commun.274,377. 7. Kamohara, M. et al.(2000)J. Biol. Chem.275,27000. 8. Wang, S. et al.(2000)J. Biol. Chem.275,39482. |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |