| 货号 | AGP-029-50ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Guinea Pig Polyclonal Antibody to NaV1.8 Channel |
| 反应种属 | R |
| 应用 | IH, WB |
| 供应商 | Alomone |
| 背景 | Voltage-gated Na+ channels (Nav) are essential for the generation of action potentials and for cell excitability1. Nav channels are activated in response to depolarization and selectively allow flow of Na+ ions. To date, nine Nav α subunits have been cloned and named Nav1.1-1.92,3. The Nav channels are classified into two groups according to their sensitivity to tetrodotoxin (TTX): TTX-sensitive and TTX-resistant channels4,5. The expression of the α subunit isoform is developmentally regulated and tissue specific. Two TTX-resistant Nav channels are expressed in dorsal root ganglion (DRG) neurons, Nav1.8 and Nav1.9. The Nav1.8 channel (also called SNS, SCN10A and PN3) is mainly expressed in small-diameter DRG neurons4-6. TTX-resistant channels have been suggested to play an important role in nociceptive transmission. Recently, involvement of Nav1.8 in multiple sclerosis (MS) was suggested due to up-regulation of both, mRNA and protein, in Purkinje cells of MS patients and also in animal models6. |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Wu, L.et al. (2002) NeuroReport13,2547. 2.Baker, M.D. et al. (2001)Trends Pharmacol. Sci.22,27. 3.Lai, J.et al. (2003) Curr. Opin. Neurobiol.13,291. 4.Fang, X.et al.(2002)J. Neurosci.22,7425. 5.Fjell, J.et al. (2000) NeuroReport11,199. 6.Renganathan, M.et al.(2003)Brain Res.959,235. |
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