| 货号 | AGP-007-50ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Guinea Pig Polyclonal Antibody to Pan Nav channels |
| 反应种属 | H, M, R |
| 应用 | WB |
| 供应商 | Alomone |
| 背景 | Voltage-gated sodium channels (Nav) are essential for the generation of action potentials and for cell excitability1. NaV channels are activated in response to depolarization and selectively allow flow of Na+ ions. To date, nine NaV α subunits have been cloned and named NaV1.1-NaV1.94,5. NaV channels are classified into two groups according to their sensitivity to Tetrodotoxin (TTX): TTX-sensitive (Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.6 and Nav1.7) and TTX-resistant (Nav1.5, Nav1.8 and Nav1.9)2,3. Mammalian Na+ channels are heterotrimers, composed of a central, pore-forming α subunit and two auxiliary β subunits. The expression of the α subunit is developmentally regulated and tissue specific. Na+ channels in the adult central nervous system and heart contain β1 through β4 subunits, whereas sodium channels in adult skeletal muscle have only the β1subunit6,7. |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Wu, L.et al.(2002)NeuroReport13,2547. 2.Fang, X.et al. (2002)J. Neurosci.22,7425. 3.Fjell, J.et al. (2000)NeuroReport11,199. 4.Baker, M.D. et al. (2001)Trends. Pharmacol. Sci.22,27. 5.Lai, J. et al.(2003)Curr. Opin. Neurobiol.13,291. 6.Isom, L.L. (2001)Neuroscientist 7,42. 7.Catterall, W.A.et al.(2003)Pharmacol. Rev. 55,575. |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |