| 货号 | AGA-005-50ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to GABA(A) δ2 Receptor |
| 反应种属 | H, M, R |
| 应用 | IC, IH, LCI, WB |
| 供应商 | Alomone |
| 背景 | The neurotransmitter GABA (γ-aminobutyric acid) inhibits the activity of signal-receiving neurons by interacting with the GABAA receptor on these cells.1 There are two major types of GABA receptors: the ionotropic GABAA(GABAA R) and the metabotropic GABAB receptors. GABAA R belongs to the ligand gated ion channel superfamily.1,2 It is a heteropentamer, with all of its five subunits contributing to the pore formation. To date, eight subunit isoforms were cloned: α, β, γ, δ, ε, π, θ, and ρ.1 The native GABAA receptor, in most cases, consists of 2α, 2β and 1γ subunit. Three γ subunits genes have been identified in mammals. The binding of GABA to its GABAA receptor results in conformational changes that open a Cl- channel, producing an increase in membrane conductance, resulting in inhibition of neural activity.2,3 Recently, a genetic linkage between familial epilepsy syndrome and mutations in the γ2 subunit of the GABAA receptor have been demonstrated.4,5 |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1. Mihic, S.J. et al.(1994)J.Neurotransmit. Rev.21,127. 2.Whiting, P.J. et al.(1999)Neurochem. Int. 34,379. 3. Ashcroft, F.M. (2000) Ion Channels and Disease Ed 1. 4.Wallace, R.H.et al.(2001)Nat. Genet. 28,49. 5.Baulac, S.et al.(2001)Nat. Genet. 28,46. |
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