| 货号 | AER-003-50ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Ployclonal Antibody to Urotensin II Receptor |
| 反应种属 | R |
| 应用 | IH, WB |
| 供应商 | Alomone |
| 背景 | Urotensin II is a very powerful vasoconstrictive substance. The human Urotensin II receptor (UTIIR) was originally isolated as an orphan receptor (GPR14) in neural and sensory tissues.1,2 Urotensin II is expressed in various human tissues such as CNS, skeletal muscle, smooth muscle, pancreas, and heart.3-5 Binding of Urotensin II to the receptor leads to activation of phospholipase C. The resulting increase in intracellular Ca2+may cause the contraction of vascular smooth muscle. ERK1/2 phophorylation may also be involved in mediating the biological activities of urotensin II.6 Recently, evidence has accumulated indicating that Urotensin II is also expressed in various kinds of tumor cells such as of adrenal tumors and neuroblastomas. In those cells Urotensin II was reported to stimulate cell growth.7-9 |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Davenport, A.P.et al.(2002)Pharmacol. Rev. 54,219. 2.Boivin, B.et al.(2003)J. Biol.Chem. 278,29153. 3.Maguire, J.J.et al.(2000)Br. J. Pharmacol. 131,441. 4.Matsushita, M.et al.(2001)J. Hypertens. 19,2185. 5.Maguire, J.J. and Davenport, A.P. (2002) Br. J. Pharmacol. 137,57. 6.Ziltener, P.et al.(2002)J. Recept. Signal Transduct. Res. 22,155. 7.Takahashi, K.et al.(2000)Clin. Sci. 103,35S. 8.Takahashi, K.et al.(2001)Peptides22,1175. 9.Takahashi, K.et al.(2003)Peptides24,301. |
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