| 货号 | ACR-051-50ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to CNTFRα |
| 反应种属 | H, M, R |
| 应用 | WB |
| 供应商 | Alomone |
| 背景 | CNTF is a polypeptide trophic factor, member of the alpha-helical cytokine superfamily1. It was initially purified from the chick eye on the basis of its ability to promote survival of E8 chick ciliary ganglion neurons in culture2. CNTF is synthesized by glia both in the CNS and PNS3 and it has been demonstrated that CNTF is ubiquitously distributed in neurons and glia throughout the rodent brain4. CNTF effects are mediated by a tripartite receptor complex consisting of two signal-transducing subunits (leukemia inhibitory factor receptor, gp130) and a CNTF-specific ligand-binding-subunit (CNTFRα)5. CNTFRα is anchored to the membrane by a glycosyl-phosphatidylinositol (GPI) linkage and lacks the intracellular signaling moiety. It can be cleaved from the GPI anchor to yield a soluble form of the receptor (sCNTFRα)6,7. CNTF binds to CNTFRα, the latter associates with gp130 which recruits LIFR. This leads to the activation of a signaling cascade involving the JAK/STAT pathway7. CNTFRα knockout mice die within 24 hours after birth as opposed to CNTF knock animals which are viable. This strongly suggest that CNTFRα has other ligands besides CNTF. Indeed, CLC/CLF complex (cardiotrophin like cytokine/cytokine-like factor-1) binds CNTFRα and activates a similar signaling pathway to that of CNTF8. |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Mufson, E.J.et al.(1999)Prog. Neurobiol. 57,451. 2.Adler, R.et al.(1979)Science204,1434. 3.Murphy, M.et al.(1997)Prog. Neurobiol. 52,355. 4.Henderson, J.T.et al.(1994)Mol. Brain Res. 22,151. 5.Stahl, N.et al. (1993) J. Biol. Chem. 268,7628. 6.Davis, S.et al.(1993)Science259,1736. 7.Vergara, C. and Ramirez, B.(2004)Brain Res. Rev.47,161. 8.Lelievre, E.et al.(2001)J. Biol. Chem.276,22476. |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |