| 货号 | ACP-002-50ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to PMCA2 Pump |
| 反应种属 | M, R |
| 应用 | WB |
| 供应商 | Alomone |
| 背景 | The plasma membrane Ca2+ ATPase (PMCA) is a transport protein in the plasma membrane of cells responsible for removing calcium (Ca2+) from the cell. This pump is vital for regulating the amount of Ca2+ within cells1. The PMCA and the Na+ calcium exchanger (NCX) are together the main regulators of intracellular Ca2+concentrations2. Since it transports Ca2+ into the extracellular space, the PMCA is also an important regulator of the Ca2+ concentration in the extracellular space3. The PMCA belongs to a family of P-type primary ion transport ATPases, and is expressed in a variety of tissues, including the brain4. The pump is powered by the hydrolysis of adenosine triphosphate (ATP), with a stoichiometry of one Ca2+ ion removed for each molecule of ATP hydrolyzed. It binds to Ca2+ ions with a high affinity (a Km of 100 to 200 nM) but does not remove Ca2+ at a very fast rate. This is in contrast to the NCX, which has a low affinity and a high capacity. Thus, the PMCA is effective at binding Ca2+ even when its concentration within the cell is very low, so it is suited for maintaining Ca2+ at its normally very low levels. The NCX is better suited for removing large amounts of Ca2+ quickly, as it is needed in neurons after an action potential. Thus the activities of the two types of pump complement each other5. |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Jensen, T.P.et al.(2004)Brain Res. Dev. Brain Res.152,129. 2.Strehler, E.E. and Zacharias, D.A.(2001) Physiol. Rev.81,21. 3.Talarico, E.F.et al. (2005)Mol. Vis.11,169. 4.Jensen, T.P.et al. (2007)J. Physiol.579,85. 5.Burette, A. and Weinberg, R.J.(2007)J. Comp. Neurol.500,1127. |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |