| 货号 | ACL-025-50ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to CLIC5 Channel |
| 反应种属 | M, R |
| 应用 | IC, WB |
| 供应商 | Alomone |
| 背景 | Chloride (Cl-) channels are membrane, anion-selective protein pores, which diffusively transport negative ions across their electrochemical gradient. Cl- channels are subdivided into six unique families, and their regulation mechanisms range from voltage-dependency, through G-protein activation, to mechanosensitivity; they may reside in either the plasma membrane or the membrane of intracellular compartments or both1. They are detected in the kidney, placenta, intestines, brain and the inner-ear1-4. The vertebrate Cl- intracellular channel (CLIC) family is composed of 6 highly conserved members (CLIC1-6); each exists as a ~250 residue protein which can assume both a soluble fold and a membrane-integral form. The latter consists of a single trans-membrane domain and is subsequently oligomerized to construct a functioning channel1,5. Interestingly, channels composed of CLIC4 and CLIC5 have been confirmed to be equally permeable to K+ and Cl-5. CLIC5, to which there are two isoforms - CLIC5A and CLIC5B - encoded by the same gene5, has first been isolated from human placenta6, and was shown, together with CLIC4 (with which it shares 76% homology), to be enriched in the apical microvilli-containing part of the trophoblast epithelium, where, unlike CLIC4, it interacts with the actin cytoskeleton4. CLIC5 shares about 40% homology with CLIC1-4 and is distributed to a high degree in myocytes, cardiomyocytes and stereocillia of the inner-ear2,4. Mice mutated in the Clic5 gene lack coordination and gradually become deaf2, show resistance to obesity, experience gastric ulcers and the resultant hemorrhage, and have higher incidence of entering torpor7. |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Jentsch, T.J. et al. (2002) Physiol. Rev. 82, 503. 2.Gagnon, L.H.et al.(2006)J. Neurosci.26,10188. 3.Wegner, B.et al.(2010)Am. J. Physiol. 298,F1492. 4.Berryman, M. and Bretscher, A.(2001)Mol. Biol. Cell11,1509. 5.Littler, D.R.et al. (2010)FEBS Letters584,2093. 6.Debska, G.et al.(2001)Acta Biochim. Polonica48,137. 7.Bradford, E.M.et al.(2010)Am. J. Physiol. 298,R1531. |
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