| 货号 | ACC-061-50ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to Orai2 Channel |
| 反应种属 | H, M, R |
| 应用 | IH, WB |
| 供应商 | Alomone |
| 背景 | Cytosolic Ca2+ has long been known to act as a key second messenger in many intracellular pathways including synaptic transmission, muscle contraction, hormonal secretion, and cell growth and proliferation.1,2 The mechanism controlling intracellular Ca2+ level influx, either by the calcium-release-activated Ca2+ channels (CRAC) or from intracellular stores, has become of great interest. Recently, several key players of the store-operated complex have been identified: the Orai family consisting of three members, Orai1-3, and the STIM family, which consists of two members, STIM1 and STIM2.3 Orai1 (also known as CRACM1) acts as the store-operated calcium channel (SOC) and STIM1 as the endoplasmic reticulum Ca2+ sensor.3,4 Orai1, Orai2, and Orai3 are all capable of forming store-operated channels.5 Co-expresssion of Orai2 and STIM1 was shown to produce currents that appear similar but smaller than those produced by co-expression of Orai1 and STIM1.6 Orai2 transcripts are predominantly expressed in kidney, lung, and spleen, and it appears that Orai2 is the only Orai isoform with multiple transcripts.7 |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Eisner, D.A. et al. (2005) Exp.Physiol. 90, 3. 2.Chakrabarti, R. and Chakrabarti, R. (2006) J.Cell. Biochem. 99, 1503. 3.Feske, S. et al. (2006) Nature 441, 179. 4.Pickett, J. (2006) Nature Reviews Mol. Cell Biol. 7, 794. 5.DeHaven, W.I. et al. (2007) J. Biol. Chem. 282, 17548. 6.Mercer, J.C.et al.(2006)J. Biol. Chem.281, 24979. 7.Gwack, Y.et al.(2007) J. Biol. Chem.282, 16232. |
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