| 货号 | ACC-060-50ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to Human Orai1 Channel |
| 反应种属 | H |
| 应用 | IFC, WB |
| 供应商 | Alomone |
| 背景 | Cytosolic calcium (Ca2+) has long been known to act as a key second messenger in many intracellular pathways including synaptic transmission, muscle contraction, hormonal secretion, cell growth and proliferation.1,2 The mechanism controlling intracellular Ca2+ level influx either by the calcium-release-activated Ca2+ channels (CRAC), or from intracellular stores, has become of great interest. Recently, several key players of the store operated complex have been identified.3 Orai1 (also known as CRACM1) acts as the store operated calcium channel (SOC) and STIM1, which acts as the endoplasmic reticulum Ca2+ sensor.3,4 The formation of functional channels by Orai1 requires the presence of both Orai1 and STIM1 proteins working as a complex that involves the co-clustering of Orai1 on the plasma membrane with STIM1 on the endoplasmic reticulum.4-6 TRPC1, a member of the transient receptor potential family was also suggested to act as a player in the SOC complex.7 In T-cells, Ca2+ entry following activation by antigen-receptor engagement occurs solely through CRAC channels where Orai1 constitutes the pore forming subunit.3,8 Orai1 is a plasma membrane protein with four potential transmembrane domains and intracellular N- and C-terminus. In addition, two mammalian homologs to Orai1 have been identified; Orai2 and Orai3.3,9 All three, Orai1 Orai2andOrai3, are capable of forming store operated channels with different magnitudes.9 |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Eisner, D.A. et al. (2005) Exp.Physiol. 90, 3. 2.Chakrabarti, R. and Chakrabarti, R. (2006) J.Cell. Biochem. 99, 1503. 3.Feske, S. et al. (2006) Nature 441, 179. 4.Pickett, J. (2006) Nature Reviews Mol. Cell Biol. 7, 794. 5.Luik, R.M. et al. (2006) J.Cell. Biol.174, 815. 6.Wu, M.M. et al. (2006) J.Cell. Biol.174, 803. 7.Hong H.L. et al. (2007) J. Biol. Chem. 282, 9105. 8.Luik, R.M and Lewis, R.S. (2007) Trends Mol. Med. 13, 103. 9.DeHaven, W.I. et al. (2007) J. Biol. Chem. 282, 17548. |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |