| 货号 | ACC-046-50ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to TRPM6 Channel |
| 反应种属 | M, R |
| 应用 | IH, WB |
| 供应商 | Alomone |
| 背景 | TRP channels are a large family (about 28 genes) of plasma membrane, non-selective cationic channels that are either specifically or ubiquitously expressed in excitable and non-excitable cells.1 The TRP channels have putative six-transmembrane domains (TM) with a pore domain between the fifth and the six TM, and all assemble as tetramers. Both the N- and the C-terminus of all TRPs are intracellular.3 According to IUPHAR the TRP family comprises of three main subfamilies on the basis of sequence homology; TRPC (canonical), TRPV (vanilloid) and TRPM (melastatin). To date, three extra subfamilies are also considered to belong to the TRP family; the TRPA, TRPML, and the TRPP.1-4 The TRPM subfamily consists of eight members, TRPM1 to TRPM8, which also can be further subdivided into four subgroups based on their sequence homology: (1)TRPM1 and TRPM3 (2) TRPM6 and TRPM7 (3) TRPM4 and TRPM5 (4) TRPM2 and TRPM8.5 |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Ramsey, S.I.et al.(2006)Annu. Rev. Physiol.68,619. 2.Pedersen, S.F.et al.(2005)Cell. Calcium.38,233. 3.Montell, C.(2005)Sci. STKE2005,re3. 4.Hilgemann, D.W.et al.(2001)Sci. STKE2001,re19. 5.Schmitz, C.et al.(2005)J. Biol. Chem.280,37763. 6.Matsushita, M.et al.(2005)J. Biol. Chem.280,20793. 7.Touyz, R.M.(2008)Am. J. Physiol.294,H1103. 8.Venkatachalam, K.et al.(2007)Annu. Rev. Biochem.76,387. 9.Walder, R.Y.et al.(2002)Nat. Genet.31,171. 10.Schlingmann, K.P.et al.(2002)Nat. Genet.31,166. |
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