| 货号 | ACC-027-50ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to TRPC2 Channel |
| 反应种属 | M, R |
| 应用 | WB |
| 供应商 | Alomone |
| 背景 | TRPC (transient receptor potential cation channel) channels are the closest mammalian homologs of Drosophila TRP and TRP-like channels. TRPCs are rather nonselective Ca2+ permeable cation channels and affect cell functions through their ability to mediate Ca2+ entry into cells and their action to collapse the plasma membrane potentials1. The mammalian genome codes for seven TRPCs of which TRPC2 is the largest with the most restricted pattern of expression and has several alternatively spliced variant2. Expressed in model cells, TRPC2 mediates both receptor- and store depletion-triggered Ca2+3. In human, TPRC2 is a pseudogene3. Physiological roles for TRPC2 have been studied in mature sperm and the vomeronasal sensory system. In sperm, TRPC2 is activated by the sperm’s interaction with the oocyte’s zona pellucida, leading to entry of Ca2+ and activation of the acrosome reaction4. In the vomeronasal sensory organ (VNO), TRPC2 was found to constitute the transduction channel activated through signaling cascade initiated by the interaction of pheromones with V1R and V2R G protein-coupled receptors on the dendrites of the sensory neurons5. TRPC2-deficient mice display abnormal mating behavior, consistent with a role for this channel in pheromone signaling6. |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1. Birnbaumer, L. et al.(1996)Proc. Natl. Acad. Sci. U.S.A.93,15195. 2. Vannier, B. et al.(1999)Proc. Natl. Acad. Sci. U.S.A.96,2060. 3. Liman, E.R. et al. (1999). Proc Natl Acad Sci USA 96, 5791. 4. Jungnickel, M.K. et al.(2001)Nat. Cell Biol.3,499. 5. Liman, E.R. et al.(1996)J. Neurosci.16,4625. 6. Stowers, L. et al.(2002)Science295,1493. |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |