| 货号 | ACC-008-50ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to CaVβ3 Subunit |
| 反应种属 | H, M, R |
| 应用 | IC, IH, WB |
| 供应商 | Alomone |
| 背景 | The β3 protein is an auxiliary subunit of the CaV (voltage dependent calcium) channel multimer complex. Four β isoforms were identified in mammalian genoms and they share some sequence as well as structure homology.1-3 The structure of CaVβ3 was recentely determined (as well as other CaVβ subunits; for review see reference 3). CaVβ subunits are cytoplasmic proteins, that bind the cytoplasmic face of the pore forming CaV α1 subunits. These interactions have profound effects on channel trafficing to the plasma membrane as well as on current parameters such as voltage dependent kinetics and interactions with modulatory proteins.1,2 CaVβ3 might interact with all the poreforming subunits that have been tested and in vivo is expressed in smooth muscle, trachea, aorta, lung and brain.1 Alomone Labs offers a polyclonal antibody directed against an epitope at the C-terminus of the auxiliary subunit CaVβ3. |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Arikkath, J. and Campbell, K.P.(2003)Curr. Opin. Neurobiol. 13, 298. 2.Dolphin, A.C.(2003) J. Bioenerg. Biomembr.35,599. 3.Richards, M.W.et al. (2004) Trends Pharmacol. Sci. 25,626. |
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