| 货号 | ACC-004-50ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Pan Polyclonal Antibody to CaV1 and CaV2 Subunits |
| 反应种属 | H, M, R |
| 应用 | IH, IP, WB |
| 供应商 | Alomone |
| 背景 | Ca2+ ions regulate many cellular processes such as secretion, proliferation, and apoptosis and they are also cofactors of many proteins.1,2 In neurons, Ca2+ entry through voltage-dependent Ca2+(Cav) channels triggers neurotransmitter release. Fast synaptic transmission in the mammalian central nervous system (CNS) is mediated by several high voltage-dependent Ca2+channels.3 Five types of Ca2+channels are expressed in the CNS: the L-type (Cav1), N-type (Cav2.2), P/Q-type (Cav2.1), R-type (Cav2.3), and the T-type (Cav3).4 Each Cavchannel is a multimeric protein composed of a pore forming α1 subunit and the auxiliary β (Cavβ), α2δ and γ subunits. There are four known Cavβ subunits, in addition to four α2δ subunits and eight γ subunits.4 |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Bonilla, M. and Cunningham, K.M.(2002)Sci. STKE 127,PE17. 2.Wu, X.et al. (2004) J. Biol. Chem. 279,43392. 3.Iwasaki, S.et al. (2000) J. Neurosci. 20,59. 4.Mark, M.D. and Herlitze, S.(2000)Eur. J. Biochem.267,5830. |
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