| 货号 | AAR-022-50ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to α2C-Adrenoceptor |
| 反应种属 | R |
| 应用 | IH, WB |
| 供应商 | Alomone |
| 背景 | Adrenoceptors (also called Adrenergic receptors) are the receptors for the catecholamines adrenaline and noradrenaline (called epinephrine and norepinephrine in the United States). Adrenaline and noradrenaline play important roles in the control of blood pressure, myocardial contractile rate and force, airway reactivity, and a variety of metabolic and central nervous system functions. The Adrenoceptors are members of the G-Protein Coupled Receptor (GPCR) superfamily of membrane proteins. They share a common structure of seven putative transmembrane domains, an extracellular N-terminus, and a cytoplasmic C- terminus.The Adrenoceptors are divided into three types: α1, α2 and β-Adrenoceptors. Each type is further divided into at least three subtypes: α1A, α1B, α1D, α2A, α2B, α2C, β1, β2, β31,2. The Adrenoceptors are expressed in nearly all peripheral tissues and in the central nervous system1,2. The α2C-Adrenoceptor subtype was identified by binding studies in the opossum kidney and in cell lines from this organ (OK cells)3,4. Surprisingly, the α2C-Adrenoceptor subtype seems not to play a major role in cardiovascular regulation or the other classical effects of α2-Adrenergic receptors5. Some researchers have suggested that the α2C-Adrenoceptor subtype may play a role in modulating motor behaviour and perhaps in memory processes6,7. |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.IUPHAR RECEPTOR DATABASE | ADRENOCEPTORS. 2. Piascik, M.T. and Perez, D. M. (2001) J. Pharmacol. Exp. Ther. 298,403. 3. Murphy, T.J. and Bylund, D.B. (1988) J. Pharmacol. Exp. Ther.244,571. 4. Blaxall, H.S. et al.(1991)J. Pharmacol. Exp. Ther.2559,323. 5. Bjorklind M. et al.(1999)Neuroscience88,1187. 6. Tanila H. et al.(1999)Eur. J. Neurosci.11,599. |
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