| 货号 | AAR-017-50ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to β3-Adrenoceptor |
| 反应种属 | M, R |
| 应用 | IH, WB |
| 供应商 | Alomone |
| 背景 | Adrenoceptors (also called Adrenergic receptors) are the receptors for the catecholamines adrenaline and noradrenaline (called epinephrine and norepinephrine in the United States). Adrenaline and noradrenaline play important roles in the control of blood pressure, myocardial contractile rate and force, airway reactivity, and a variety of metabolic and central nervous system functions. The Adrenoceptors are members of the G-protein-coupled receptor (GPCR) superfamily of membrane proteins. They share a common structure of seven putative transmembrane domains, an extracellular amino terminus, and a cytoplasmic carboxyl terminus.The Adrenoceptors are divided into three types: α1, α2 and β-Adrenoceptors. Each type is further divided into at least three subtypes: α1A, α1B, α1D, α2A, α2B, α2C, β1, β2, β3. 1,2 The Adrenoceptors are expressed in nearly all peripheral tissues and in the central nervous system.1,2 The β3-Adrenoceptor is insensitive to the commonly used ß-antagonists and has often been referred to as the 'atypical' ß-Adrenoceptor. Mouse β3-Adrenoceptor has two known splice variants, isoforms β3a-Adrenoceptor and β3b-Adrenoceptor. Both isoforms are expressed in white and brown adipose tissues.3 The β3b-Adrenoceptor is highly exspressed in brain. The β3- Adrenoceptor has been found to play a key role in the lipolytic action of catecholamines.4 |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.IUPHAR RECEPTOR DATABASE | ADRENOCEPTORS 2. Piascik, M. T .and Perez, D. M. (2001) J. Pharmacol. Exp. Ther. 298,403. 3. Evans, B. A. et al.(1999)Br. J. Pharmacol.127,1525. 4. Klein, J. et al(1999)J.Biol.Chem.274,34795. |
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