| 货号 | AAR-006-50ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to A1 Adenosine Receptor |
| 反应种属 | H, M, R |
| 应用 | IC, IH, WB |
| 供应商 | Alomone |
| 背景 | Adenosine is an endogenous nucleoside generated locally in tissues under conditions of hypoxia, ischemia, or inflammation. It modulates a variety of physiological functions in many tissues including brain and heart.1,2 It exerts its action via four specific adenosine receptors (also named P1 purinergic receptors): A1-Adenosine Receptor (A1AR),A2A-Adenosine Receptor(A2AAR),A2B-Adenosine Receptor(A2BAR), and A3-Adenosine Receptor(A3AR). All are integral membrane proteins and members of the G Protein-Coupled Receptor superfamily. They share a common structure of seven putative transmembrane domains, an extracellular amino terminus, a cytoplasmic carboxyl terminus, and a third intracellular loop that is important in binding G proteins.1-3 The various adenosine receptors can be distinguished on the basis of their differential selectivity for adenosine analogs.1-3 A1AR is widely distributed and has been well characterized. High expression of A1AR is found in brain (mainly in the cortex, cerebellum, and hippocampus), dorsal horn of the spinal cord, adrenal gland, and atria, and to a lower extent in several other tissues including adipose tissue, colon, and kidney.2,4 A1AR modulates the activity of several ion channels. Activation of A1AR (by adenosine, its major agonist) inhibits N-type Ca2+ channels via a voltage-dependent, pertussis toxin (PTX)-sensitive pathway in neurons of the rat major pelvic ganglia (MPG).5 Since A1AR is the most prominent adenosine receptor in adipocytes, it has become a natural target for research on obesity, which is a major health problem.6,7 A possible role in cell proliferation and carcinogenesis has also been suggested for A1AR.8-10 |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Okusa, M.D. (2002) Am. J. Physiol.282,F10. 2.Nakata, H.(1989)J. Biol. Chem.264,16545. 3.Linden, J. (1991) FASEB J.5, 2668. 4.Park, K-S.et al.(2001)J. Pharmacol. Exp. Therap. 299, 501. 5.Rice, A.M.et al.(2000)Endocrinology141,1442. 6.LaNoue, K.F. and Martin, L.F. (1994) FASEB J. 8, 72. 7.Synowitz, M.et al.(2006)Cancer Res.66,8550. 8.Lelievre, V.et al.(1998)Eur. J. Pharmacol.341,289. 9.Khoo, H.E.et al.(1996)Cancer Lett.106,17. |
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