| 货号 | AZT-013-25ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to ZnT3 |
| 反应种属 | H, M, R |
| 应用 | IH, WB |
| 供应商 | Alomone |
| 背景 | ZnT3 is a member of the SLC30 family of zinc transporters which promotes the influx of zinc ions into synaptic vesicles of glutamatergic neurons from the cytoplasm, intracellular organelles, or to the outside of the cell. It is responsible for maintaining high intravesicular zinc content. ZnT3 is encoded by the Slc30a3 gene and is selectively located on the vesicles of zinc-secreting neurons. ZnT3 is also present in regions of the brain such as the hippocampus and neocortex1. Ionic zinc is found ubiquitously throughout synapses of the mammalian central nervous system, where it plays fundamental roles in synaptic function and plasticity2. ZnT3 structure is predicted to contain six transmembrane spanning domains that form a pore lined with a histidine-rich loop3. Knockout of ZnT3 leads to the absence of histochemically reactive zinc in the terminals of zincergic neurons. A loss in ZnT3 might lead to disturbances in brain functions such as memory function, emotions, behavior, motivation, and in the processing of sensory information3,4. Studies have shown that genetic absence of ZnT3 may be involved in the synaptic and memory deficits of Alzheimer's disease1. Another study showed that a knockout mouse has a tendency for seizure5. |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Adlard, P.A.et al.(2010)J. Neurosci. 30,1631. 2.Salazar, G. et al. (2005) J.Cell Sci. 118,1911. 3.Wojtkiewicz, J.et al.(2012) J. Mol. Neurosci.48,766. 4.Hagmeyer, S.et al.(2015)Front. Behav. Neurosci.8,443. 5.Frederickson, C.J.et al.(2000)J. Nutr.130,1471S. |
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