| 货号 | AVR-003-25ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to PAC1 Receptor |
| 反应种属 | M, R |
| 应用 | IH, WB |
| 供应商 | Alomone |
| 背景 | Pituitary adenylate cyclase-activating polypeptide (PACAP, encoded by ADCYAP1 gene) belongs a superfamily of structurally related peptide hormones, which include vasoactive intestinal peptide (VIP), glucagon, glucagon-like peptides, secretin, gastric inhibitory peptide and growth hormone-releasing hormone. PACAP acts through PAC1, VPAC1andVPAC2, initiating multiple signaling pathways1. PAC1 is a class B member of the G-protein coupled receptors (GPCRs) superfamily. Class B receptors are differentiated from Class A by a relatively large N-terminal ectodomain that is crucial to ligand recognition2. PAC1R is mainly expressed on smooth muscle cells, neurons, endothelial cells and peritoneal macrophages3. PAC1R is associated with posttraumatic stress disorder (PTSD) symptoms and psychophysiological markers of fear and anxiety4. PAC1 receptor null mice demonstrate reduced anxiety-like behavior5. In addition, PAC1 overexpression can result in hydrocephalus- and schizophrenia-related neuropathology1. |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Shen, S.et al. (2013) Neuropeptides47,421. 2.Couvineau, A. and Laburthe, M.(2012)Br. J. Pharmacol.166,42. 3.Banki, E.et al.(2014)Neuropharmacology85,538. 4.Stevens, J.S. et al.(2014)Proc. Natl. Acad. Sci. U.S.A.111,3158. 5.Hattori, S.et al. (2012) Front. Behav. Neurosci.6,58. |
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