| 货号 | ATR-021-25ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to Trace Amine Receptor 1 |
| 反应种属 | H, M, R |
| 应用 | WB |
| 供应商 | Alomone |
| 背景 | Trace amines are compounds such as p-tyramine and tryptamine found in the body in trace amounts as their name implies. These substances were believed to mainly modulate aminergic pathways. However, they were found to activate Trace amino associated receptors (TAARs), members of the G-protein coupled receptor (GPCRs) superfamily1. Trace amine receptor 1 (TAAR-1) is part of the Rhodopsin family of GPCRs. Five other putative genes are thought to encode TAAR receptors. This receptor has a seven transmembrane domain with short extracellular N- and intracellular C- terminal domains. TAAR-1 couples Gs, thus leading to an increase in intracellular cAMP levels. Its signaling might be enhanced by monoamine transporters, and activation of TAAR-1 may also affect monoamine transport function. The receptor also inhibits PKA and PKC mediated dopamine uptake and PKC mediated dopamine efflux2. It is also possible that it forms heterodimers with dopamine receptors, thus influencing dopamine transmission3. In humans, this receptor is mainly expressed in the stomach but is also detected in the lungs, small intestine and many cerebral and cerebellar tissues including the amygdala, hypothalamus and others4. In experiments conducted in mice it was shown that TAAR-1 knockout mice display increased stimulation effects of d-amphetamine, greater levels of extracellular monoamine and hyperactivity. These effects are related to clinical conditions such as ADHD, psychosis and other psychiatric problems5. Additional studies on TAAR family receptors may be helpful in finding cutting edge treatment. |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Maguire, J.J.et al. (2009)Pharmacol. Rev. 61,1. 2.Miller, G.(2011)J. Neurochem.116,164. 3.Sotnikova, T.et al. (2009)Mol. Pharmacol. 76,229. 4.Borowsky, B.et al.(2001)Proc. Natl. Acad. Sci. U.S.A.98,8966. 5.Wolinsky, T.D.et al. (2006)Genes Brain. Behav. 6,628. |
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