| 货号 | ASR-036-25ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to 5-Hydroxytryptamine Receptor 4 |
| 反应种属 | R |
| 应用 | IC, LCI, WB |
| 供应商 | Alomone |
| 背景 | 5-hydroxytryptamine receptor 4 (5-HT4 receptors) are a subclass among the large family of receptors mediating serotonin actions at central and peripheral targets. 5-HT4 receptor activation has been implicated in learning and memory, feeding control and stress response. 5-HT4 receptors are encoded by a complex gene which in humans, generates ten different splice variants1, 2. The 5-HT4 receptor, a member of the seven transmembrane spanning G-protein-coupled receptors (GPCRs), couples via Gs to increase cAMP production. GPCRs share a similar topology, with seven transmembrane helices (TMHs) connected by three extracellular loops (ECLs), and three intracellular loops (ICLs); the N-terminus is on the extracellular side of the membrane, and the C-terminus is on the cytoplasmic side3. Within the central nervous system, these receptors are expressed in limbic structures including: hypothalamus, nucleus accumbens, prefrontal cortex, amygdala and hippocampus, where they contribute to emotional and cognitive functions4. Low levels of 5-HT4 receptors are associated with numerous neuropsychiatric disorders including Alzheimer's disease, Huntington’s disease, feeding disorders and stress-related disorders such as anxiety and depression5. |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Mnie-Filali, O.et al.(2010)Cell. Signal.22,501. 2.Barnes, N.M. and Sharp, T.(1999)Neuropharmacology38,1083. 3.Oh, D.Y.et al. (2006) Int. Rev. Cytol.252,163. 4.Bockaert, J.et al.(2004)Curr. Drug Targets CNS Neurol. Disord.3,39. 5.Varnas, K.et al. (2003) Eur. Neuropsychopharmacol.13,228. |
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