| 货号 | ASR-033-25ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to 5-Hydroxytryptamine Receptor 2A |
| 反应种属 | H, M, R |
| 应用 | IH, WB |
| 供应商 | Alomone |
| 背景 | 5-HT is involved in a diverse array of physiologic and biologic processes. In the brain, 5-HT affects sleep, mood, appetite, anxiety, aggression, perception, pain, and cognition1. Signaling of 5-HT is mediated by receptors that are located on the cell membrane of neurons and most other cells in the body. The 5-HT2 family consists of three G-protein coupled receptors (GPCRs): 5-HT2A, 5-HT2B, and 5-HT2C2. They are transmembrane proteins consisting of seven membrane-spanning α-helical segments with an extracellular N-terminus and an intracellular C-terminus. The binding of 5-HT to one of its receptors is thought to elicit a conformational change that activates associated heterotrimeric G proteins and recruits other downstream signaling/scaffolding molecules, such as GPCR kinases and β-arrestins. 5-HT2A receptors have been found in many regions of the human brain including: the cortex, brainstem areas, olfactory bulb, limbic system and basal ganglia3. 5-HT2A receptor has been implicated in many mental disorders including: schizophrenia, depression, obsessive compulsive disorder (OCD), attention deficit–hyperactivity disorder (ADHD), and eating disorders such as anorexia nervosa and autism spectrum disorders4. |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Hutcheson, J.D. et al. (2011) Pharmacol. Ther. 132, 146. 2.Fitzgerald, L.W. et al. (2000) Mol. Pharmacol. 57, 75. 3.Lorke, D.E.et al.(2006)BMC Neurosci.7,36. 4. Raote, I. et al. (2007) Chattopadhyay A, editor. Serotonin receptors in neurobiology. Boca Raton, FL: CRC Press. 105. |
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