| 货号 | ASC-009-25ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to NaV1.6 Channel |
| 反应种属 | H, M, R |
| 应用 | IC, IH, WB |
| 供应商 | Alomone |
| 背景 | Voltage-gated sodium channels(NaV) are essential for the generation of action potentials and for cell excitability.1NaV channels are activated in response to depolarization and selectively allow flow of Na+ ions. To date, nine NaV α subunits have been cloned and named NaV1.1-NaV1.9.4-5 The NaV channels are classified into two groups according to their sensitivity to Tetrodotoxin (TTX): TTX-sensitive (NaV1.1,NaV1.2,NaV1.3,NaV1.4, NaV1.6 and NaV1.7) and TTX-resistant (NaV1.5,NaV1.8andNaV1.9).2-3 Mammalian sodium channels are heterotrimers, composed of a central, pore-forming α subunit and two auxiliary β subunits. Expression of the α subunit isoform is developmentally regulated and tissue specific. Sodium channels in the adult central nervous system and heart contain β1 through β4 subunits, whereas sodium channels in adult skeletal muscle have only the β1subunit.6,7 NaV1.6 is highly expressed in adult brain and localized at high density in nodes of Ranvier and axon initial segments and at lower density in dendrites and cell bodies of some neurons. NaV1.6 channels are also expressed at high levels in cerebellar Purkinje neurons.8-11 |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Wu, L.et al.(2002)NeuroReport13,2547. 2.Fang, X.et al. (2002)J. Neurosci.22,7425. 3.Fjell, J.et al. (2000)NeuroReport11,199. 4.Baker, M.D. and Wood, J.N.(2001)Trends Pharmacol. Sci.22,27 5.Lai, J. et al.(2003)Curr.Opin. Neurobiol13,291. 6.Isom, L.L. (2001)Neuroscientist 7,42. 7.Catterall, W.A.et al.(2003)Pharmacol. Rev 55,575. 8.Catterall, W.A.et al.(2005)Pharmacol Rev.57,397. 9.Boiko, T.et al.(2001)Neuron30,91. 10.Caldwell, J.H. et al.(2000)Proc. Natl. Acad. Sci. U.S.A. 97,5616. 11.Raman I. M and Bean B.P. (1997)J. Neurosci.17,4517 |
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