| 货号 | ASC-008-25ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to NaV1.7 Channel |
| 反应种属 | H, M, R |
| 应用 | IC, IH, WB |
| 供应商 | Alomone |
| 背景 | Voltage-gated sodium channels (NaV) are essential for the generation of action potentials and for cell excitability.1Nav channels are activated in response to depolarization and selectively allow flow of Na+ ions. To date, nine Nav α subunits have been cloned and named NaV1.1-NaV1.9.4-5 The NaV channels are classified into two groups according to their sensitivity to Tetrodotoxin (TTX): TTX-sensitive (NaV1.1, NaV1.2, NaV1.3, NaV1.4, NaV1.6 and NaV1.7) and TTX-resistant (NaV1.5, NaV1.8 and NaV1.9).2-3 Mammalian sodium channels are heterotrimers, composed of a central, pore-forming α subunit and two auxiliary β subunits. Expression of the α subunit isoform is developmentally regulated and tissue specific. Sodium channels in the adult central nervous system and heart contain β1 through β4 subunits, whereas sodium channels in adult skeletal muscle have only the β1subunit.6-8 NaV1.7 is predominantly expressed in dorsal root ganglions (DRG) of the peripheral nervous system. Dominant gain of function mutations in the NaV1.7 gene are associated with erythermalgia (a rare autosomal disease characterized by sporadic burning pain accompanied by redness and heat in the extremities).9-11 Loss, or function mutations in NaV1.7 channels, leads to complete ablation of pain perception in humans.11 These recent findings highlight the role of this NaV isoform and the subset of DRG neurons that express this channel in physiological pain sensation. |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Wu, L.et al.(2002)NeuroReport13,2547. 2. Fang, X.et al. (2002)J. Neurosci.22,7425. 3.Fjell, J.et al. (2000)NeuroReport11,199. 4.Baker, M.D. and Wood, J.N. (2001) Trends Pharmacol. Sci.22,27. 5.Lai, J. et al.(2003)Curr. Opin. Neurobiol.13,291. 6.Isom, L.L.(2001)Neuroscientist 7,42. 7.Catterall, W.A.et al.(2003)Pharmacol Rev 55,575. 8.Catterall, W.A.et al.(2005)Pharmacol. Rev.57,397. 9.Yang, Y.et al. (2004)J. Med. Genet. 41,171. 10.Cummins, T.R.et al. (2004)J. Neurosci. 24,8232. 11.Dray, A. (2008) Br. J. Anaesth.101,48. |
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