| 货号 | AQP-011-25ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to Aquaporin 11 Channel |
| 反应种属 | M, R |
| 应用 | WB |
| 供应商 | Alomone |
| 背景 | The aquaporins (AQP), also known as the major intrinsic protein superfamily (MIP), are a family of integral membrane proteins. In mammals, 13 aquaporins were described (AQP0 – AQP12). Aquaporin 11 (AQP11) is a newly described member of the aquaporins family. Aquaporin-11 (AQP-11) has been identified with unusual pore-forming NPA (asparagine-proline-alanine) boxes. AQP-11 presents a conserved structure of six transmembrane domains with intracellular N- and C-termini. The functional channel is a tetramer but each subunit has a separate pore and therefore the functional channel unit, contains four pores1. There are two subfamilies: the aquaporins, which transport only water and the aquaglyceroporins, which transport glycerol, urea, and other small solutes in addition to water2. Aquaporins and aquaglyceroporins are ubiquitously expressed, including in the plasma membrane of renal epithelia, brain astrocytes, and red blood cells3. AQP-11 is expressed in several tissues including testis, kidney, liver, and brain. In the brain, AQP11 is found in Purkinje cells, hippocampal neurons of CA1 and CA2, and cerebral cortical neurons4. In the kidney AQP-11 has a central role in vesicular homeostasis as demonstrated in experiments using AQP-11 knockout mice which display growth retardation and progressively die before weaning. The cause of death seems to be advanced renal failure5. |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.King, L.S.et al.(2004)Nat. Rev. Mol. Cell Biol.5,687. 2.Borgnia, M.et al.(1999)Annu Rev Biochem68,425. 3.Yasui, M.et al. (1999) Proc Natl Acad Sci,96,5808. 4.Gorelick, D.A.et al.(2006)BMC Biochem.7,14. 5.Morishita, Y.et al.(2005)Mol. Cell Biol.25,7770. |
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