| 货号 | APZ-014-25ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to PICK1 |
| 反应种属 | H, M, R |
| 应用 | IH, WB |
| 供应商 | Alomone |
| 背景 | PICK1 interacts with the PDZ motifs of several proteins, including: protein kinase C α (PKC α), glutamate receptors (GluRs), prolactin-releasing peptide (PrRP), acid-sensing ion channel(ASICs),dopamine transporter (DAT), Karlirin 7, ephrin type-B receptor 2 (EphB2),ErbB2 / Her-2, TIS21, coxsackie virus and adenovirus receptor (CXADR), and UNC5H. The proteins interacting with PICK1 have roles in synaptic plasticity, neuronal cell morphology, and mitochondrial-dependent apoptosis. In most of the cases, PICK1 acts as a critical regulator of membrane receptors' subcellular trafficking to modulate neural processes such as learning and memory1. PICK1 is widely expressed in brain, testis, heart, lung, liver, kidney and muscle2. Its abnormal expression in brain has been linked to drug abuse and dependence, schizophrenia, and psychosis. Recent evidence suggest that PICK1 may affect human cancer development3,4. PICK1 has also been reported to be expressed in insulin-producing pancreatic beta-cells where it may play a role in the neuroendocrine system5. |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Bolia, A.et al.(2012)Proteins80,1393. 2.Staudinger, J.et al.(1995) J. Cell Biol.128,263. 3.Zhao, B. et al.(2012)Cell Res.22,1467. 4.Zhang, B.et al. (2010) Cancer Sci.101,1536. 5.Jensen, L.J. et al.(2009)Nucleic Acids Res.37,D412. |
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