| 货号 | APZ-010-25ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to SAP-97 |
| 反应种属 | H, M, R |
| 应用 | WB |
| 供应商 | Alomone |
| 背景 | SAP-97 belongs to the MAGUK (membrane associated guanylate kinase) homologs along with PSD-95,PSD-93andSAP102. Like other members, SAP-97 has three PDZ domains, one SH3 domain and an inactive GUK domain. Alternative splicing of SAP-97 gives to a number of different isoforms thereby complicating the understanding of its roles1. In the post-synaptic cell, SAP-97 is the only MAGUK to directly interact with the GluA1 AMPA receptor2. SAP-97 also directly interacts with NMDA receptors through the PDZ domain3,4. SAP-97 was shown to interact with KV1.45 and with KV4.2 where it directs the channel to spines in hippocampal neurons6. It can also interact with the channel in the heart7. Interactions with Kirchannels have also been observed8,9. Thus, SAP-97 serves as a regulator of neuronal excitability and synaptic function. Roles for the protein in schizophrenia, Alzheimer’s and Parkinson’s disease and epilepsy have been found1. |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Fourie, C.et al.(2014)Biochim. Biophys. Acta1838,589. 2.Leonard, A.S.et al.(1998)J. Biol. Chem.273,19518. 3.Howard, M.A.et al.(2010)Proc. Natl. Acad. Sci. U.S.A.107,3805. 4.Sheng, M. and Sala, C.(2001)Annu. Rev. Neurosci.24,1. 5.Kim, E. and Sheng, M.(1996)Neuropharmacology35,993. 6.Gardoni, F.et al.(2007)J. Biol. Chem.282,28691. 7.El Haou, S.et al.(2009)Circ. Res.104,758. 8.Leonoudakis, D.et al.(2004)J. Biol. Chem.279,22331. 9.Leonoudakis, D.et al.(2001)J. Cell Sci.114,987. |
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