| 货号 | APR-063-25ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit polyclonal antibody to the Prostanoid EP1 Receptor |
| 反应种属 | H, M, R |
| 应用 | IC, LCI, WB |
| 供应商 | Alomone |
| 背景 | Prostaglandin (PG) E2 is involved in a number of physiological and pathophysiological events in many tissues throughout the body. The biological effects of PGE2 are mediated through interaction with specific membrane-bound G-protein-coupled prostanoid EP2 receptors. There are four subtypes of the EP receptor, termed EP1, EP2, EP3 and EP4, which have been defined on the basis of their different pharmacological profiles and signal transduction pathwas 1. EP1 is characterized by the presence of a helical bundle consisting of seven hydrophobic transmembrane helices (TM1-TM7), which are connected through six alternating extracellular and intracellular loops. The N-terminus is located on the extracellular side of the membrane, whereas the C-terminus occupies the intracellular side2. EP1 receptors are thought to mediate contraction of smooth muscle in various tissues such as the gastrointestinal tract, respiratory tract, vas deferens, myometrium and the iris sphincter muscle and may also be important for absorption inhibition in the small intestine as well as enhancement of neuronal activity3. Human colon cancer cells express the EP1 receptor. Furthermore EP1 receptor antagonists inhibit chemically induced breast cancer development in rats and reduce the number of skin tumors per mouse following UVB exposure4,5. |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Funk, D.C.et al. (1993) J. Biol. Chem.268,26767. 2.Zare, B.et al.(2011) Sci. Pharm.79,793. 3.Sun, B.et al.(2013)Mol. Cell. Biochem.378,195. 4.O’Callaghan, G.et al. (2013) Int. J. Cancer133,825. 5.Bergmann, C.et al. (2007) Cancer Res.67,8865. |
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