| 货号 | APR-015-25ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to P2Y11 Receptor |
| 反应种属 | H |
| 应用 | IC, IFC, WB |
| 供应商 | Alomone |
| 背景 | The P2Y receptors belong to the G-protein coupled receptors superfamily. They mediate the actions of the extracellular nucleotides (ATP, ADP, UTP and UDP). Eight functional mammalian P2Y receptors have been described: P2Y1,P2Y2,P2Y4, P2Y6, P2Y11, P2Y12,P2Y13, and the UDP-glucose receptor, now renamed P2Y14.1-3 The human P2Y11 receptor is unique among the P2Y receptors since it is dually coupled to phospholipase C and adenylyl cyclase.4-5 P2Y11 receptor is highly pressed in spleen and for much lower extent at platelets. Expression of P2Y11 receptor was also shown in endothelial cells.6 In granulocytes HL-60), P2Y11 receptor is thought to have a role in granulocytic differentiation.4,7 |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Queiroz, G.et al. (2003) J. Pharmacol. Exp. Ther.307, 809. 2.Ralevic, V. and Burnstock, G.(1998)Pharmacol. Rev.50,413. 3.Abbracchio, M.P.et al. (2003) Trends. Pharmacol. Sci.24,52. 4.Communi, D.et al.(2000)FEBS Letters475,39. 5.White, P.J.et al.(2003)Mol. Pharmacol. 63,1356. 6.Wang, L.et al. (2002) J. Cardiovas. Pharmacol.40,841. 7.IUPHAR. |
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