| 货号 | APR-010-25ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to P2Y2 Receptor |
| 反应种属 | H, M, R |
| 应用 | IC, IFC, IH, IP, WB |
| 供应商 | Alomone |
| 背景 | The P2Y receptors belong to the G-protein coupled receptors superfamily. P2Y receptors mediate the actions of the extracellular nucleotides (ATP, ADP, UTP and UDP) and regulate several physiological responses, among them, cardiac function, platelet aggregation and SMC proliferation.1 The mammalian P2Y family currently includes eight functional receptors;P2Y1, P2Y2, P2Y4,P2Y6,P2Y11,P2Y12,P2Y13, and the UDP-glucose receptor, now renamed P2Y14.2-4 P2Y2 receptor is abundantly expressed in the apical membranes of several epithelial tissues including airway.5 P2Y2 receptor has become a leading candidate for the treatment of cystic fibrosis. Activation of P2Y2 receptor increases Cl- efflux and mucociliary clearance, effects that might relieve symptoms of cystic fibrosis. P2Y2 agonist therapy is tested in an attempt to bypass the dysfunctioning CFTR channel. Several P2Y2 receptor agonists, especially INS37217, being evaluated as possible targets for the treatment of cystic fibrosis.6 |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Wang, L.et al. (2002) J. Cardiovas. Pharmacol.40,841. 2.Queiroz, G.et al. (2003) J. Pharmacol. Exp. Ther.307, 809. 3.Ralevic, V. and Burnstock, G.(1998)Pharmacol. Rev.50,413. 4.Abbracchio, M.P.et al. (2003) Trends. Pharmacol. Sci.24,52. 5.Di Virgilio, F.et al. (2001) Blood97,587. 6.Yerxa, B.R.et al. (2002) J. Pharmacol. Exp. Ther.302,871. |
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