| 货号 | APR-008-25ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to P2X7 Receptor |
| 反应种属 | H, M, R |
| 应用 | IC, IFC, IH, LCI, WB |
| 供应商 | Alomone |
| 背景 | The P2X7 receptor is a member of the ionotropic P2X receptor family that is activated by ATP. To date, this family is composed of seven cloned receptor subtypes, named P2X1-P2X7. The different P2X receptors show distinct expression patterns. P2X1-6 have been found in the central and peripheral nervous system, while the P2X7 receptor is found in cells of the immune system, particularly antigen presenting cells, and microglia. The P2X7 receptor mediates the release of proinflamatory cytokines, stimulation of transcription factors and may also have an important role in apoptosis.1-3 Different techniques have been used to characterize the P2X7 receptor. Most of them investigated pores, ion channels (electrophysiology) and membrane alterations (calcium microfluorometry, dye uptake, membrane depolarization and ion influx analysis). With the introduction of flow cytometry, it is now possible to analyze multiple cell parameters such as cell cycle, cell membrane alteration, calcium influx and cell phenotype.4 |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Ding, Y.et al.(2000)J. Auton. Nerv. Syst. 81,289. 2.Kim, M.et al.(2001)EMBO J. 20,6347. 3.Chizh, B.A. and Illes, P.(2001)Pharmacol. Rev. 53,553. 4.Nihei, O.K.et al.(2000)Mem.Inst.Oswaldo Cruz. 95,415. |
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