| 货号 | APC-146-25ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to DPP6 |
| 反应种属 | H, M, R |
| 应用 | IH, WB |
| 供应商 | Alomone |
| 背景 | Dipeptidyl-peptidase 6 (DPP6) is a type II membrane glycoprotein1 which is a part of the dipeptydil aminopeptidase-like proteins (DPPLs) subfamily. It is an auxiliary, glycoproteinic subunit of voltage dependent K+ channel 4 (KV4.x) that has a short cytoplasmic domain, a long extracellular domain and a transmembrane domain. It regulates sub-threshold, A-type K+ currents, and is important for the enhancement and localization of KV4.2 channels2. DPPLs are a subgroup of the larger prolyl oligopeptidase family. A loss-of-function mutation at their enzymatic serine renders them incapable of cleaving peptides. Notable DPPLs include DPP8, DPP9, and DPPIV – the latter is known to regulate several key functions in varied systems, ranging from immune to CNS1,3. Alternative mRNA splicing of the DPP6 gene (part of the di-genic DPLP group that also consists DPP10) gives rise to several isoforms that differ in their N-terminal (DPP6a, DPP6K, DPP6S, DPP6L DPP6E)4. DPP6 proteins are widely expressed throughout both of the nervous systems – albeit much more predominantly in the CNS - and are known to play a major role in neurogenesis and neurodevelopment5. Deletion mutations and haplo-insufficiency of the DPP6 gene has been shown to be associated with autism spectrum disorder, Gilles de la Tourette syndrome, dominant microcephaly and mental retardation5,6. Endometriosis – a condition characterized by extra-uteral endometrial glands that affects one tenth of fertile women population – has been linked with DPP6 in genome wide associations studies (GWASs)7. |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Lin, L.et al.(2014)J. Biol. Chem. pii: jbc.M114.578070. 2.Jerng, H.H. and Pfaffinger, P.J.(2012)PLoS One7,e38205. 3.Busek, P.et al.(2004)Int. J. Biochem. Cell. Biol.36,408. 4.Lin, L.et al.(2013)Nat. Commun.4,2270. 5.Liao, C.et al.(2013)Eur. J. Med. Genet.56,484. 6.Prontera, P.et al.(2014)Neurogenetics15,237. 7.Chettier, R.et al.(2014)PLoS One9,e103968. |
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