| 货号 | APC-142-25ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to KChIP2 Subunit |
| 反应种属 | H, M, R |
| 应用 | IH, WB |
| 供应商 | Alomone |
| 背景 | KChIPs belong to the family of small cytosolic calcium-binding proteins and consists of four different KChIP isoform ranging between 216 and 270 amino acids. They all have a reasonably conserved core region of 185 amino acids and a heterogeneous N-terminal. KChIPs have calcium-binding EF hands which appear important for modulation KVchannels but not for CaVchannels1. The cardiac KChIP2 gene generates three protein isoforms of 220, 252, and 270 amino acids via alternative splicing of exons 2 and 3. It is well established that KChIP2 functionally increases peak KV4 current, slows channel inactivation and accelerates recovery from inactivation. Furthermore, KChIP2 has been reported to increase I Ca ,L and suggested to decrease KV1.5 cell surface expression and facilitate INa2. All four KChIP mRNAs are found in the brain; however only KChIP2 is expressed in the heart3. KChIP2 is expressed heterogeneously across the canine and human left and right ventricular free wall with higher concentrations in epicardium compared to endocardium4. Mice deficient for KChIP2 exhibit normal cardiac structure and function but display a prolonged elevation in the ST segment on the electrocardiogram. The KChIP2−/− mice are highly susceptible to the induction of cardiac arrhythmias5. |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Holmqvist, M.H.et al.(2002)Proc. Natl. Acad. Sci. U.S.A.99,1035. 2.Lundby, A. et al.(2010)Br. J. Pharmacol. 160,2028. 3.Rosati, B.et al.(2001)J. Physiol. (Lond.)533,119. 4.Grubb, S.et al.(2012)Front. Physiol.3,118. 5.Kuo, H.C.et al.(2001)Cell107,801. |
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